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KMID : 0895820100200010013
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Journal of Oriental Rehabilitation Medicine
2010 Volume.20 No. 1 p.13 ~ p.26
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Neuroprotective Effects of Neutral Pharmacopuncture for Blood Stasis and Tangguisusangami-tang(dangguixusanjiawei-tang ) in the Experimental Traumatic Brain Injury Rats
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Chung Il-Moon
Choi Jin-Bong
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Abstract
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Objectives : This study was designed to evaluate neuroprotective effects of Neutral Pharmacopuncture for Blood Stasis(NPBS) into SP10 and Tangguisusangami-tang (dangguixusanjiawei-tang)(TGT) in the experimental Traumatic Brain Injury(TBI) rats.
Methods : Male rats were divided into 4 groups. Group Ⅰ was no treatment after TBI. Group Ⅱ was treatment with NPBS into SP10 after TBI. Group Ⅲ was treatment with TGT after TBI. Group Ⅳ was NPBS into SP10 and TGT after TBI. The author carried out neurological motor behavioral, histological assessment test.
Results : 1. In neurological motor behavior tests, motor and cognitive function recovery was significantly increased in the Group Ⅱ, Ⅲ, Ⅳ. Also Group Ⅳ was increased as compared with Group Ⅱ, Ⅲ. 2. In BAX expression, according to priority Group Ⅳ, Ⅲ, Ⅱ, Ⅰ were decresed in 7 and 14 days later. Especially Group Ⅳ was significantly decreased in 14days later. 3. In BCL-2 expression, Group Ⅳ was increased slightly in 7days later. Most incresed expression was experimented in the Group Ⅳ in 14days later. 4. In TUNEL expression, Ⅳ was decreased as compared with each Group Ⅰ,Ⅱ, Ⅲ in 7days later. Group Ⅳ, Ⅲ were decreased as compared with each Group Ⅰ,Ⅱ in 14days later.
Conclusions : According to the results, NPBS and TGT can inhibit apoptosis of cells after TBI in rats by contol of BAX and BCL-2, TUNEL expression. And also can help neurological motor behavioral function.
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KEYWORD
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SP10, NeutralPharmacopunctureforBloodstasis, Tangguisusangami-tang(dangguixusanjiawei-tang), Neuroprotectiveeffec
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